Correlation between SEPS1 gene polymorphism and type 2 diabetes mellitus: A preliminary study.

ABSTRACT:

Background

The protein encoded by the selenoprotein S gene is considered to be an anti-inflammatory and antioxidant protein and is involved in a variety of diseases. Therefore, we want to study the distribution characteristics of this gene in Chinese diabetic population.

Methods

A total of 170 patients with DM (including 100 patients with T2DM and 70 patients with diabetic nephropathy [DN]) and 100 healthy controls (HC) were selected from Haikou People's Hospital (China) between January 2017 and July 2017. The polymorphisms of three SEPS1 genes (SNP ID: rs4965814, rs28665122, and rs34713741) were measured by massARRAY method, while the polymorphisms of SEPS1 genes (SNP ID: rs4965373) were detected by Sanger sequencing.

Results

Comparing three groups, the results were

SUBMITTER: Li F 

PROVIDER: S-EPMC6805276 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature