Association between nucleotide excision repair gene polymorphism and colorectal cancer risk.

ABSTRACT:

Background

The nucleotide excision repair system removes a wide variety of DNA lesions from the human genome, and plays an important role in maintaining genomic stability. Single nucleotide polymorphisms (SNPs) in nucleotide excision repair are associated with the various forms of tumor susceptibility. However, the relationship between NER polymorphism and colorectal cancer is not clear.

Methods

In this study, three candidate SNPs including ERCC4 (rs6498486), ERCC1 (rs3212986), and ERCC5 (rs17655) were analyzed in 1101colorectal cancer patients and 1175 healthy control patients from Jiangsu province (China). Then, we performed Immunohistochemistry, qPCR, and luciferase assay to determine the potential mechanisms.

Results

The ERCC4 rs6498486 AC/CC genotypes show lower

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC6805325 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature