Rescue fecal microbiota transplantation for antibiotic-associated diarrhea in critically ill patients.

ABSTRACT:

Background

Antibiotic-associated diarrhea (AAD) is a risk factor for exacerbating the outcome of critically ill patients. Dysbiosis induced by the exposure to antibiotics reveals the potential therapeutic role of fecal microbiota transplantation (FMT) in these patients. Herein, we aimed to evaluate the safety and potential benefit of rescue FMT for AAD in critically ill patients.

Methods

A series of critically ill patients with AAD received rescue FMT from Chinese fmtBank, from September 2015 to February 2019. Adverse events (AEs) and rescue FMT success which focused on the improvement of abdominal symptoms and post-ICU survival rate during a minimum of 12 weeks follow-up were assessed.

Results

Twenty critically ill patients with AAD underwent rescue FMT, and 18 of th

SUBMITTER: Dai M 

PROVIDER: S-EPMC6805332 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature