Characterization of five newly derived canine osteosarcoma cell lines.

ABSTRACT:

Background

Canine and human osteosarcomas (OS) are notably similar and have a high rate of metastasis. There is a poor understanding of the tumor development process, predisposing causes, and varying levels of aggression among different cell lines. By characterizing newly developed canine osteosarcoma cell lines, treatments for people and pets can be developed. Of the seven subtypes of OS, three are represented in this group: osteoblastic (the most common), fibroblastic, and giant cell variant. To our knowledge, there are no other giant cell variant canine OS cell lines in the published literature and only one canine fibroblastic osteosarcoma cell line. Understanding the differences between the histologic subtypes in dogs will help to guide comparative research.

Results

Alka

SUBMITTER: Wilson-Robles H 

PROVIDER: S-EPMC6805340 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature