Prognostic values of microRNA-130 family expression in patients with cancer: a meta-analysis and database test.

ABSTRACT:

Background

Emerging evidence shows that microRNA-130 (miRNA-130) family may be useful as prognostic biomarkers in cancer. However, there is no confirmation in an independent validation study. The aim of this study was to summarize the prognostic value of miRNA-130 family (miRNA-130a and miRNA-130b) for survival in patients with cancer.

Methods

The pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated to estimate the association strength between miRNA-130 family expression and prognosis. Kaplan-Meier plotters were used to verify the miRNA-130b expression and overall survival (OS).

Results

A total of 2141 patients with OS and 1159 patients with disease-free survival (DFS)/progression-free survival (PFS) were analyzed in evidence synthesis. For t

SUBMITTER: Peng Z 

PROVIDER: S-EPMC6805372 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature