Inter- and intra-breed genome-wide copy number diversity in a large cohort of European equine breeds.

ABSTRACT:

Background

Copy Number Variation (CNV) is a common form of genetic variation underlying animal evolution and phenotypic diversity across a wide range of species. In the mammalian genome, high frequency of CNV differentiation between breeds may be candidates for population-specific selection. However, CNV differentiation, selection and its population genetics have been poorly explored in horses.

Results

We investigated the patterns, population variation and gene annotation of CNV using the Axiom® Equine Genotyping Array (670,796 SNPs) from a large cohort of individuals (N = 1755) belonging to eight European horse breeds, varying from draught horses to several warmblood populations. After quality control, 152,640 SNP CNVs (individual markers), 18,800 segment CNVs (consecutive

SUBMITTER: Sole M 

PROVIDER: S-EPMC6805398 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature