Targeting of prostate-specific membrane antigen for radio-ligand therapy of triple-negative breast cancer.

ABSTRACT:

Background

Triple-negative breast cancer has extremely high risk of relapse due to the lack of targeted therapies, intra- and inter-tumoral heterogeneity, and the inherent and acquired resistance to therapies. In this study, we evaluate the potential of prostate-specific membrane antigen (PSMA) as target for radio-ligand therapy (RLT).

Methods

Tube formation was investigated after incubation of endothelial HUVEC cells in tumor-conditioned media and monitored after staining using microscopy. A binding study with ⁶⁸Ga-labeled PSMA-addressing ligand was used to indicate targeting potential of PSMA on tumor-conditioned HUVEC cells. For mimicking of the therapeutic application, tube formation potential and vitality of tumor-conditioned HUVEC cells were assessed followi

SUBMITTER: Morgenroth A 

PROVIDER: S-EPMC6805467 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature