Rapid adaptation of signaling networks in the fungal pathogen Magnaporthe oryzae.

ABSTRACT:

Background

One fundamental question in biology is how the evolution of eukaryotic signaling networks has taken place. "Loss of function" (lof) mutants from components of the high osmolarity glycerol (HOG) signaling pathway in the filamentous fungus Magnaporthe oryzae are viable, but impaired in osmoregulation.

Results

After long-term cultivation upon high osmolarity, stable individuals with reestablished osmoregulation capacity arise independently from each of the mutants with inactivated HOG pathway. This phenomenon is extremely reproducible and occurs only in osmosensitive mutants related to the HOG pathway - not in other osmosensitive Magnaporthe mutants. The major compatible solute produced by these adapted strains to cope with high osmolarity is glycerol, whereas it is

SUBMITTER: Bohnert S 

PROVIDER: S-EPMC6805500 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature