Linezolid use in German acute care hospitals: results from two consecutive national point prevalence surveys.

ABSTRACT: Background:Linezolid belongs to a reserve group of antibiotics. In recent years, reports on linezolid resistance in gram-positive cocci have become more frequent. Overuse of linezolid is a relevant factor for resistance development. The objective of this study was to describe current prescription practices of linezolid in German hospitals and identify targets for antimicrobial stewardship interventions. Methods:We analyzed all linezolid prescriptions from the datasets of the consecutive national point prevalence surveys performed in German hospitals in 2011 and 2016. In both surveys, data on healthcare-associated infections and antimicrobial use were collected following the methodology of the European Centre for Disease Prevention and Control. Results:Overall, the percentage of linezolid a

SUBMITTER: Kramer TS 

PROVIDER: S-EPMC6805522 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature