Detecting multiple differentially methylated CpG sites and regions related to dimensional psychopathology in youths.

ABSTRACT: BACKGROUND:Psychiatric symptomatology during late childhood and early adolescence tends to persist later in life. In the present longitudinal study, we aimed to identify changes in genome-wide DNA methylation patterns that were associated with the emergence of psychopathology in youths from the Brazilian High-Risk Cohort (HRC) for psychiatric disorders. Moreover, for the differentially methylated genes, we verified whether differences in DNA methylation corresponded to differences in mRNA transcript levels by analyzing the gene expression levels in the blood and by correlating the variation of DNA methylation values with the variation of mRNA levels of the same individuals. Finally, we examined whether the variations in DNA methylation and mRNA levels were correlated with psychopathology m

SUBMITTER: Spindola LM 

PROVIDER: S-EPMC6805541 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature