The high-affinity IgG receptor FcγRI modulates peripheral nerve injury-induced neuropathic pain in rats.

ABSTRACT: The Fc gamma receptor I (FcγRI; CD64) is the high-affinity receptor of the immunoglobulin G protein (IgG). It is usually expressed in immune cells and has recently been identified to distribute in the nervous system and play critical roles in various neurological disorders. Presently, the impacts of FcγRI in neuropathic pain was largely unknown. Here, we aimed to investigate the impacts of FcγRI in neuropathic pain through pain-related neurobehavioral studies and underlying mechanisms by biochemical methods in animal and cell models. Specifically, we first utilized the chronic constriction injury (CCI) rat model that displayed neuropathic pain related symptoms and signs, including thermal hyperalgesia and mechanical allodynia. These neurobehavioral defects were significantly attenuated by

SUBMITTER: Liang Y 

PROVIDER: S-EPMC6805563 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature