External quality assessment (EQA) program for the immunohistochemical detection of ER, PR and Ki-67 in breast cancer: results of an interlaboratory reproducibility ring study in China.

ABSTRACT:

Background

An External Quality Assessment (EQA) program was developed to investigate the status of estrogen receptor (ER), progesterone receptor (PR), and Ki-67 immunohistochemical (IHC) detection in breast cancer and to evaluate the reproducibility of staining and interpretation in 44 pathology laboratories in China.

Methods

This program was implemented through three specific steps. In study I, three revising centres defined the reference value for 11 sections. In study II, 41 participating centres (PC) stained and interpreted 11 sections by their own daily practice IHC protocols. In study III, all cases received second interpretation opinions.

Results

The stained slides of 44 laboratories were up to the interpretation standard. The overall interpretation concordance

SUBMITTER: Pu T 

PROVIDER: S-EPMC6805628 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature