RUNX1 mutations promote leukemogenesis of myeloid malignancies in ASXL1-mutated leukemia.

ABSTRACT:

Background

Additional sex combs-like 1 (ASXL1) mutations have been described in all forms of myeloid neoplasms including chronic myelomonocytic leukemia (CMML) and associated with inferior outcomes, yet the molecular pathogenesis of ASXL1 mutations (ASXL1-MT) remains poorly understood. Transformation of CMML to secondary AML (sAML) is one of the leading causes of death in CMML patients. Previously, we observed that transcription factor RUNX1 mutations (RUNX1-MT) coexisted with ASXL1-MT in CMML and at myeloid blast phase of chronic myeloid leukemia. The contribution of RUNX1 mutations in the pathogenesis of myeloid transformation in ASXL1-mutated leukemia, however, remains unclear.

Methods

To evaluate the leukemogenic role of RUNX1-MT in ASXL1-mutated cells, we co-expressed R

SUBMITTER: Bera R 

PROVIDER: S-EPMC6805634 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature