Age-treatment subgroup analyses in Cochrane intervention reviews: a meta-epidemiological study.

ABSTRACT:

Background

There is growing interest in evaluating differences in healthcare interventions across routinely collected demographic characteristics. However, individual subgroup analyses in randomized controlled trials are often not prespecified, adjusted for multiple testing, or conducted using the appropriate statistical test for interaction, and therefore frequently lack credibility. Meta-analyses can be used to examine the validity of potential subgroup differences by collating evidence across trials. Here, we characterize the conduct and clinical translation of age-treatment subgroup analyses in Cochrane reviews.

Methods

For a random sample of 928 Cochrane intervention reviews of randomized trials, we determined how often subgroup analyses of age are reported, how often t

SUBMITTER: Liu P 

PROVIDER: S-EPMC6805640 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature