Molecular characterization of hepatitis C virus in liver disease patients in Botswana: a retrospective cross-sectional study.

ABSTRACT:

Background

Hepatitis C virus (HCV) infection is a major cause of chronic liver disease globally. Direct acting antivirals (DAAs) have proven effective in curing HCV. However, the current standard of care (SOC) in Botswana remains PEGylated interferon-α (IFN-α) with ribavirin. Several mutations have been reported to confer resistance to interferon-based treatments. Therefore, there is a need to determine HCV genotypes in Botswana, as these data will guide new treatment guidelines and understanding of HCV epidemiology in Botswana.

Methods

This was a retrospective cross-sectional pilot study utilizing plasma obtained from 55 participants from Princess Marina Hospital in Gaborone, Botswana. The partial core region of HCV was amplified, and genotypes were determined using phyloge

SUBMITTER: Bhebhe L 

PROVIDER: S-EPMC6805647 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature