MLH1 deficiency leads to deregulated mitochondrial metabolism.
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ABSTRACT:
SUBMITTER: Rashid S
PROVIDER: S-EPMC6805956 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Publications
MLH1 deficiency leads to deregulated mitochondrial metabolism.
Rashid Sukaina S Freitas Marta O MO Cucchi Danilo D Bridge Gemma G Yao Zhi Z Gay Laura L Williams Marc M Wang Jun J Suraweera Nirosha N Silver Andrew A McDonald Stuart A C SAC Chelala Claude C Szabadkai Gyorgy G Martin Sarah A SA
Cell death & disease 20191022 11
The DNA mismatch repair (MMR) pathway is responsible for the repair of base-base mismatches and insertion/deletion loops that arise during DNA replication. MMR deficiency is currently estimated to be present in 15-17% of colorectal cancer cases and 30% of endometrial cancers. MLH1 is one of the key proteins involved in the MMR pathway. Inhibition of a number of mitochondrial genes, including POLG and PINK1 can induce synthetic lethality in MLH1-deficient cells. Here we demonstrate for the first ...[more]
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