Induction of tumor-specific CD8⁺ cytotoxic T lymphocytes from naive human T cells by using Mycobacterium-derived mycolic acid and lipoarabinomannan-stimulated dendritic cells.

ABSTRACT: The main effectors in tumor control are the class I MHC molecule-restricted CD8⁺ cytotoxic T lymphocytes (CTLs). Tumor-specific CTL induction can be regulated by dendritic cells (DCs) expressing both tumor-derived epitopes and co-stimulatory molecules. Immunosuppressive tolerogenic DCs, having down-regulated co-stimulatory molecules, are seen within the tumor mass and can suppress tumor-specific CTL induction. The tolerogenic DCs expressing down-regulated XCR1⁺CD141⁺ appear to be induced by tumor-derived soluble factors or dexamethasone, while the immunogenic DCs usually express XCR1⁺CD141⁺ molecules with a cross-presentation function in humans. Thus, if tolerogenic DCs can be reactivated into immunogenic DCs with sufficient co-stimula

SUBMITTER: Tomita Y 

PROVIDER: S-EPMC6805962 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature