In search of causal pathways in diabetes: a study using proteomics and genotyping data from a cross-sectional study.

ABSTRACT:

Aims/hypothesis

The pathogenesis of type 2 diabetes is not fully understood. We investigated whether circulating levels of preselected proteins were associated with the outcome 'diabetes' and whether these associations were causal.

Methods

In 2467 individuals of the population-based, cross-sectional EpiHealth study (45-75 years, 50% women), 249 plasma proteins were analysed by the proximity extension assay technique. DNA was genotyped using the Illumina HumanCoreExome-12 v1.0 BeadChip. Diabetes was defined as taking glucose-lowering treatment or having a fasting plasma glucose of ≥7.0 mmol/l. The associations between proteins and diabetes were assessed using logistic regression. To investigate causal relationships between proteins and diabetes, a bidirectional two-sample Men

SUBMITTER: Beijer K 

PROVIDER: S-EPMC6805963 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature