Clustering as a Means To Control Nitrate Respiration Efficiency and Toxicity in Escherichia coli.

ABSTRACT: Respiration is a fundamental process that has to optimally respond to metabolic demand and environmental changes. We previously showed that nitrate respiration, crucial for gut colonization by enterobacteria, is controlled by polar clustering of the nitrate reductase increasing the electron flux through the complex. Here, we show that the formate dehydrogenase electron-donating complex, FdnGHI, also clusters at the cell poles under nitrate-respiring conditions. Its proximity to the nitrate reductase complex was confirmed by its identification in the interactome of the latter, which appears to be specific to the nitrate-respiring condition. Interestingly, we have identified a multiprotein complex dedicated to handle nitric oxide resulting from the enhanced activity of the electron transport

SUBMITTER: Bulot S 

PROVIDER: S-EPMC6805990 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature