Pharmaco-electroencephalographic responses in the rat differ between active and inactive locomotor states.

ABSTRACT: Quantitative electroencephalography from freely moving rats is commonly used as a translational tool for predicting drug-effects in humans. We hypothesized that drug-effects may be expressed differently depending on whether the rat is in active locomotion or sitting still during recording sessions, and proposed automatic state-detection as a viable tool for estimating drug-effects free of hypo-/hyperlocomotion-induced effects. We aimed at developing a fully automatic and validated method for detecting two behavioural states: active and inactive, in one-second intervals and to use the method for evaluating ketamine, DOI, d-cycloserine, d-amphetamine, and diazepam effects specifically within each state. The developed state-detector attained high precision with more than 90% of the detected t

SUBMITTER: Hansen IH 

PROVIDER: S-EPMC6806018 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature