µ-Opioid Activity in Chronic TMD Pain Is Associated with COMT Polymorphism.

ABSTRACT: Clinicians have the dilemma of prescribing opioid or nonopioid analgesics to chronic pain patients; however, the impact of pain on our endogenous µ-opioid system and how our genetic profile (specifically catechol-O-methyltransferase [COMT] polymorphisms) impacts its activation are currently unknown. Twelve chronic temporomandibular disorder (TMD) patients and 12 healthy controls (HCs) were scanned using positron emission tomography (PET) with [¹¹C]carfentanil, a selective radioligand for µ-opioid receptors (µORs). The first 45 min of each PET measured the µOR nondisplaceable binding potential (BP_ND) at resting state, and the last 45 min consisted of a 20-min masseteric pain challenge with an injection of 5% hypertonic saline. Participants were also genotyped fo

SUBMITTER: Nascimento TD 

PROVIDER: S-EPMC6806132 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature