Association of Acquired and Heritable Factors With Intergenerational Differences in Age at Symptomatic Onset of Alzheimer Disease Between Offspring and Parents With Dementia.

ABSTRACT:

Importance

Acquired and heritable traits are associated with dementia risk; however, how these traits are associated with age at symptomatic onset (AAO) of Alzheimer disease (AD) is unknown. Identifying the associations of acquired and heritable factors with variability in intergenerational AAO of AD could facilitate diagnosis, assessment, and counseling of the offspring of parents with AD.

Objective

To quantify the associations of acquired and heritable factors with intergenerational differences in AAO of AD.

Design, setting, and participants

This nested cohort study used data from the Knight Alzheimer Disease Research Center that included community-dwelling participants with symptomatic AD, parental history of dementia, and available DNA data who were enrolled in pr

SUBMITTER: Day GS 

PROVIDER: S-EPMC6806434 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature