Changes in ESCRT-III filament geometry drive membrane remodelling and fission in silico.

ABSTRACT:

Background

ESCRT-III is a membrane remodelling filament with the unique ability to cut membranes from the inside of the membrane neck. It is essential for the final stage of cell division, the formation of vesicles, the release of viruses, and membrane repair. Distinct from other cytoskeletal filaments, ESCRT-III filaments do not consume energy themselves, but work in conjunction with another ATP-consuming complex. Despite rapid progress in describing the cell biology of ESCRT-III, we lack an understanding of the physical mechanisms behind its force production and membrane remodelling.

Results

Here we present a minimal coarse-grained model that captures all the experimentally reported cases of ESCRT-III driven membrane sculpting, including the formation of downward and upwar

SUBMITTER: Harker-Kirschneck L 

PROVIDER: S-EPMC6806514 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature