Palbociclib in combination with simvastatin induce severe rhabdomyolysis: a case report.

ABSTRACT:

Background

Palbociclib is a selective well-tolerated antineoplastic drug used in the treatment of advanced HER2-negative, estrogen-receptor positive breast cancer that has shown significant improvement in progression-free survival. We present a patient that developed severe rhabdomyolysis with tetra-affection and loss of gait after initiating the first cycle of Palbociclib concomitantly with Simvastatin 40 mg treatment.

Case presentation

A 71-year-old woman with metastatic breast cancer developed tetraparesis and near fatal rhabdomyolysis after initiation of first cycle Palbociclib. For 10 years prior to this treatment, the patient had been treated with Simvastatin without myalgia or other neuromuscular complaints prior to the first cycle of Palbociclib. The patient was admi

SUBMITTER: Nersesjan V 

PROVIDER: S-EPMC6806583 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature