Minocycline microspheres did not significantly improve outcomes after collagenase injection of tendon.

ABSTRACT:

Background

Tetracycline antibiotics inhibit matrix metalloproteinases and pro-inflammatory cytokines implicated in the pathogenesis of tendinopathy, while microsphere formulations allow sustained release of drug contents. The purpose of this study was to evaluate the ability of a local minocycline microsphere injection to restore normal tendon properties in a rat model of collagenase-induced patellar tendinopathy.

Methods

A total of 22 rats were randomly assigned to the control (n = 11) or minocycline (n = 11) group and received bilateral patellar tendon injections of collagenase. After 7 days, the minocycline group received the minocycline microsphere treatment and the control group received phosphate buffered solution. Pain was assessed via activity monitors and Von Frey f

SUBMITTER: Allen AD 

PROVIDER: S-EPMC6806656 | biostudies-literature | 2019 Nov-Dec

REPOSITORIES: biostudies-literature