Anti-Mitotic Spindle Apparatus Antoantibodies: Prevalence and Disease Association in Chinese Population.

ABSTRACT:

Background

Mitotic spindle apparatus (MSA) antibodies are rare findings with undefined clinical significance in clinical research. We aimed at investigating the prevalence and clinical significance of anti-MSA antibodies in Chinese population.

Methods

Between 2008 and 2013, a total of 180,180 patients were studied for the presence of anti-MSA antibodies. The clinical details and laboratory data of anti-MSA-positive patients were retrospectively collected and analyzed.

Results

Of the 180,180 patients tested, 68,640 patients presented with positive antinuclear antibodies (ANAs, 38.10%), but only 32 patients with positive anti-MSA antibodies (0.018%). Diagnoses were established in 22 of 32 patients: 16 connective tissue diseases (CTDs), mainly Sjogren syndrome (SS, 5/16)

SUBMITTER: Xi Q 

PROVIDER: S-EPMC6806695 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature