Recall Responses from Brain-Resident Memory CD8⁺ T Cells (bT_RM) Induce Reactive Gliosis.

ABSTRACT: HIV-associated neurocognitive disorders (HAND) persist even during effective combination antiretroviral therapy (cART). Although the cause of HAND is unknown, studies link chronic immune activation, neuroinflammation, and cerebrospinal fluid viral escape to disease progression. In this study, we tested the hypothesis that specific, recall immune responses from brain-resident memory T cells (bT_RM) could activate glia and induce neurotoxic mediators. To address this question, we developed a heterologous prime-central nervous system (CNS) boost strategy in mice. We observed that the murine brain became populated with long-lived CD8⁺ bT_RM, some being specific for an immunodominant Gag epitope. Recall stimulation using HIV-1 AI9 peptide administered in vivo resu

SUBMITTER: Prasad S 

PROVIDER: S-EPMC6807101 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature