A reduced form of nicotinamide riboside defines a new path for NAD⁺ biosynthesis and acts as an orally bioavailable NAD⁺ precursor.

ABSTRACT:

Objective

A decay in intracellular NAD⁺ levels is one of the hallmarks of physiological decline in normal tissue functions. Accordingly, dietary supplementation with NAD⁺ precursors can prevent, alleviate, or even reverse multiple metabolic complications and age-related disorders in diverse model organisms. Within the constellation of NAD⁺ precursors, nicotinamide riboside (NR) has gained attention due to its potent NAD⁺ biosynthetic effects in vivo while lacking adverse clinical effects. Nevertheless, NR is not stable in circulation, and its utilization is rate-limited by the expression of nicotinamide riboside kinases (NRKs). Therefore, there is a strong interest in identifying new effective NAD⁺ precursors that can overcome

SUBMITTER: Giroud-Gerbetant J 

PROVIDER: S-EPMC6807296 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature