The role of serum VCAM-1 and TNF-α as predictors of mortality and morbidity in patients with chronic heart failure.

ABSTRACT:

Background

To assess the prognostic significance of four inflammatory markers (TNF-α, high sensitive C-reactive protein (hs-CRP), intercellular cell adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1)) in chronic heart failure (CHF) patients with respect to individual outcomes, especially disease exacerbation and mortality.

Methods

Plasma adhesion molecules, ICAM-1, and VCAM-1, together with TNF-α and hs-CRP were determined in 120 CHF patients and 69 healthy controls. Endothelial function was also estimated by flow-mediated brachial artery dilatation.

Results

Increased levels of all investigated inflammatory markers were found in CHF patients compared to controls, with the rise more pronounced in New York Heart association (NYHA) functional IV cla

SUBMITTER: Savic-Radojevic A 

PROVIDER: S-EPMC6807553 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature