Interactions between structural remodeling and volumetric growth in right ventricle in response to pulmonary arterial hypertension.

ABSTRACT: Pulmonary arterial hypertension (PAH) exerts substantial pressure overload on the right ventricle (RV). The associated RV free wall (RVFW) adaptation could consist of myocardial hypertrophy, augmented intrinsic contractility, collagen fibrosis, and structural remodeling in an attempt to cope with pressure overload. If RVFW adaptation cannot maintain the RV stroke volume, RV dilation will prevail as an exit mechanism which usually decompensates the RV function leading to RV failure. Our knowledge of the factors determining the transition from the upper limit of RVFW adaptation to RV decompensation and the role of fiber remodeling events in this transition remains very limited. Computational heart models that connect the growth and remodeling (G\&R) events at the fiber and tissue levels with

SUBMITTER: Avazmohammadi R 

PROVIDER: S-EPMC6807999 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature