Anisotropic Material Characterization of Human Cervix Tissue Based on Indentation and Inverse Finite Element Analysis.

ABSTRACT: The cervix is essential to a healthy pregnancy as it must bear the increasing load caused by the growing fetus. Preterm birth is suspected to be caused by the premature softening and mechanical failure of the cervix. The objective of this paper is to measure the anisotropic mechanical properties of human cervical tissue using indentation and video extensometry. The human cervix is a layered structure, where its thick stromal core contains preferentially aligned collagen fibers embedded in a soft ground substance. The fiber composite nature of the tissue provides resistance to the complex three-dimensional loading environment of pregnancy. In this work, we detail an indentation mechanical test to obtain the force and deformation response during loading which closely matches in vivo conditio

SUBMITTER: Shi L 

PROVIDER: S-EPMC6808002 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature