Site-Specific Load-Induced Expansion of Sca-1⁺Prrx1⁺ and Sca-1^-Prrx1⁺ Cells in Adult Mouse Long Bone Is Attenuated With Age.

ABSTRACT: Aging is associated with significant bone loss and increased fracture risk, which has been attributed to a diminished response to anabolic mechanical loading. In adults, skeletal progenitors proliferate and differentiate into bone-forming osteoblasts in response to increasing mechanical stimuli, though the effects of aging on this response are not well-understood. Here we show that both adult and aged mice exhibit load-induced periosteal bone formation, though the response is significantly attenuated with age. We also show that the acute response of adult bone to loading involves expansion of Sca-1⁺Prrx1⁺ and Sca-1^-Prrx1⁺ cells in the periosteum. On the endosteal surface, loading enhances proliferation of both these cell populations, though the r

SUBMITTER: Cabahug-Zuckerman P 

PROVIDER: S-EPMC6808224 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature