Pathophysiological role of prostanoids in coagulation of the portal venous system in liver cirrhosis.

ABSTRACT:

Background

Prostanoids are important regulators of platelet aggregation and thrombotic arterial diseases. Their involvement in the development of portal vein thrombosis, frequent in decompensated liver cirrhosis, is still not investigated.

Methods

Therefore, we used pro-thrombotic venous milieu generation by bare metal stent transjugular intrahepatic portosystemic shunt insertion, to study the role of prostanoids in decompensated liver cirrhosis. Here, 89 patients receiving transjugular intrahepatic portosystemic shunt insertion were included in the study, and baseline levels of thromboxane B2, prostaglandin D2 and prostaglandin E2 were measured in the portal and the hepatic vein.

Results

While the hepatic vein contained higher levels of thromboxane B2 than the portal

SUBMITTER: Queck A 

PROVIDER: S-EPMC6808498 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature