The Changing Epidemiology of HIV-Associated Adult Meningitis, Uganda 2015-2017.

ABSTRACT:

Background

Central nervous system (CNS) infections remain a major public health problem in Sub-Saharan Africa, causing 15%-25% of AIDS-related deaths. With widespread availability of antiretroviral therapy (ART) and the introduction of improved diagnostics, the epidemiology of infectious meningitis is evolving.

Methods

We prospectively enrolled adults presenting with HIV-associated meningitis in Kampala and Mbarara, Uganda, from March 2015 to September 2017. Participants had a structured, stepwise diagnostic algorithm performed of blood cryptococcal antigen (CrAg), CSF CrAg, Xpert MTB/RIF for tuberculous (TB) meningitis (TBM), Biofire multiplex polymerase chain reaction, and traditional microscopy and cultures.

Results

We screened 842 consecutive adults with HIV prese

SUBMITTER: Ellis J 

PROVIDER: S-EPMC6810358 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature