Inference and analysis of population-specific fine-scale recombination maps across 26 diverse human populations.

ABSTRACT: Fine-scale rates of meiotic recombination vary by orders of magnitude across the genome and differ between species and even populations. Studying cross-population differences has been stymied by the confounding effects of demographic history. To address this problem, we developed a demography-aware method to infer fine-scale recombination rates and applied it to 26 diverse human populations, inferring population-specific recombination maps. These maps recapitulate many aspects of the history of these populations including signatures of the trans-Atlantic slave trade and the Iberian colonization of the Americas. We also investigated modulators of the local recombination rate, finding further evidence that Polycomb group proteins and the trimethylation of H3K27 elevate recombination rates. F

SUBMITTER: Spence JP 

PROVIDER: S-EPMC6810367 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature