Probing demyelination and remyelination of the cuprizone mouse model using multimodality MRI.

ABSTRACT:

Background

Various studies by MRI exhibit that the corpus callosum (CC) is the most vulnerable to cuprizone administration, detecting the demyelination and remyelination process using different MRI parameters are, however, lacking.

Purpose

To investigate the sensitivity of multiparametric MRI both in vivo and ex vivo for demyelination and remyelination.

Study type

Prospective.

Animal model

A cuprizone mice model with an age-matched control group (n = 5), 4-week cuprizone exposure group followed by 9-week on a normal diet (n = 6), and a 13-week cuprizone exposure group (n = 6).

Field strength/sequence

3D gradient recalled echo, T₂ -weighted, and diffusion tensor imaging (DTI) at 7.0T and 9.4T.

Assessment

Quantification of DTI metrics, qu

SUBMITTER: Wang N 

PROVIDER: S-EPMC6810724 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature