Altered large-scale functional brain networks in neurological Wilson's disease.

ABSTRACT: Wilson's disease patients with neurological symptoms have motor symptoms and cognitive deficits, including frontal executive, visuospatial processing, and memory impairments. Although the brain structural abnormalities associated with Wilson's disease have been documented, it remains largely unknown how Wilson's disease affects large-scale functional brain networks. In this study, we investigated functional brain networks in Wilson's disease. Particularly, we analyzed resting state functional magnetic resonance images of 30 Wilson's disease patients and 26 healthy controls. First, functional brain networks for each participant were extracted using an independent component analysis method. Then, a computationally efficient pattern classification method was developed to identify discriminati

SUBMITTER: Jing R 

PROVIDER: S-EPMC6810801 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature