A novel device to measure static hindlimb weight-bearing forces in pronograde rodents.

ABSTRACT:

Background

Joint pain is composed of both spontaneous and movement-induced pain. In animal models, static bodyweight distribution is a surrogate for spontaneous joint pain. However, there are no commercially-available instruments that measure static bodyweight distribution in normal, pronograde rodents.

New method

We designed a Static Horizontal Incapacitance Meter (SHIM) to measure bodyweight distribution in pronograde standing rodents. We assessed the device for feasibility, repeatability, and sensitivity to quantify hindlimb bodyweight distribution. Mice and rats with unilateral inflammatory pain induced by subcutaneous injections of capsaicin or Complete Freund's Adjuvant (CFA) into the plantar surface of the left hind paw were used to measure static weight-bearing. The

SUBMITTER: Williams MD 

PROVIDER: S-EPMC6810897 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature