2616. Genetic Susceptibility to Life-Threatening Respiratory Syncytial Virus Infection in Previously Healthy Infants

ABSTRACT: Abstract

Background

Differential expression of selected immunity genes may have a role in susceptibility to Respiratory Syncytial Virus (RSV). There are few data about some candidate gene single nucleotide polymorphisms (SNPs) associated with the severity of respiratory infections (e.g., Toll-like receptor 4 [TLR4], Toll-like receptor 8 [TLR8], macrophage receptor with colagenous structure [MARCO], myxovirus resistance 1 [MX1]). The aims of this study were to detect the presence of SNPs in selected genes of previously healthy infants infected with RSV, to assess viral load (VL) and to analyze their relationship with life-threatening disease (LTD)

Methods

Prospective cohort study including previously healthy full-term infants < 12 months, hospitalized with a first RSV infe

SUBMITTER: Ferolla F 

PROVIDER: S-EPMC6810930 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature