KRAS status is related to histological phenotype in gastric cancer: results from a large multicentre study.

ABSTRACT: BACKGROUND:Gastric cancer (GC) is histologically a very heterogeneous disease, and the temporal development of different histological phenotypes remains unclear. Recent studies in lung and ovarian cancer suggest that KRAS activation (KRASact) can influence histological phenotype. KRASact likely results from KRAS mutation (KRASmut) or KRAS amplification (KRASamp). The aim of the study was to investigate whether KRASmut and/or KRASamp are related to the histological phenotype in GC. METHODS:Digitized haematoxylin/eosin-stained slides from 1282 GC resection specimens were classified according to Japanese Gastric Cancer Association (JGCA) and the Lauren classification by at least two observers. The relationship between KRAS status, predominant histological phenotype and clinicopathological var

SUBMITTER: Hewitt LC 

PROVIDER: S-EPMC6811379 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature