Square Biphasic Pulse Deep Brain Stimulation for Parkinson's Disease: The BiP-PD Study.

ABSTRACT:

Background

Conventional Parkinson's disease (PD) deep brain stimulation (DBS) utilizes a pulse with an active phase and a passive charge-balancing phase. A pulse-shaping strategy that eliminates the passive phase may be a promising approach to addressing movement disorders.

Objectives

The current study assessed the safety and tolerability of square biphasic pulse shaping (sqBIP) DBS for use in PD.

Methods

This small pilot safety and tolerability study compared sqBiP versus conventional DBS. Nine were enrolled. The safety and tolerability were assessed over a 3-h period on sqBiP. Friedman's test compared blinded assessments at baseline, washout, and 30 min, 1 h, 2 h, and 3 h post sqBIP.

Results

Biphasic pulses were safe and well tolerated by all participants. Sq

SUBMITTER: De Jesus S 

PROVIDER: S-EPMC6811491 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature