Transcriptomic and barrier responses of human airway epithelial cells exposed to cannabis smoke.

ABSTRACT: Globally, many jurisdictions are legalizing or decriminalizing cannabis, creating a potential public health issue that would benefit from experimental evidence to inform policy, government regulations, and user practices. Tobacco smoke exposure science has created a body of knowledge that demonstrates the conclusive negative impacts on respiratory health; similar knowledge remains to be established for cannabis. To address this unmet need, we performed in vitro functional and transcriptomic experiments with a human airway epithelial cell line (Calu-3) exposed to cannabis smoke, with tobacco smoke as a positive control. Demonstrating the validity of our in vitro model, tobacco smoke induced gene expression profiles that were significantly correlated with gene expression profiles from publis

SUBMITTER: Aguiar JA 

PROVIDER: S-EPMC6811686 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature