Mesenchymal Stromal Cells Anno 2019: Dawn of the Therapeutic Era? Concise Review.

ABSTRACT: 2018 was the year of the first marketing authorization of an allogeneic stem cell therapy by the European Medicines Agency. The authorization concerns the use of allogeneic adipose tissue-derived mesenchymal stromal cells (MSCs) for treatment of complex perianal fistulas in Crohn's disease. This is a breakthrough in the field of MSC therapy. The last few years have, furthermore, seen some breakthroughs in the investigations into the mechanisms of action of MSC therapy. Although the therapeutic effects of MSCs have largely been attributed to their secretion of immunomodulatory and regenerative factors, it has now become clear that some of the effects are mediated through host phagocytic cells that clear administered MSCs and in the process adapt an immunoregulatory and regeneration supporti

SUBMITTER: Hoogduijn MJ 

PROVIDER: S-EPMC6811696 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature