The novel cannabinoid CB₁ receptor agonist AM11101 increases food intake in female rats.

ABSTRACT:

Background and purpose

Δ⁹ -tetrahydrocannabinol (THC) acts via cannabinoid CB₁ receptors to increase feeding. Here, we assessed the orexigenic effect of AM11101, a novel CB₁ receptor agonist designed to have a more favourable pharmacodynamic profile than THC.

Experimental approach

The acute, orexigenic effects of AM11101 and THC were compared in female rats. Food intake and meal patterns were also examined following once daily treatment with AM11101 and THC for 7 days.

Key results

AM11101 (0.01-0.1 mg·kg^-1 ) increased food intake during the first hour following both acute and chronic treatments in pre-fed and freely feeding animals. This orexigenic effect persisted for up to 4 hr, with no compensatory decrease in feeding dur

SUBMITTER: Ogden SB 

PROVIDER: S-EPMC6811743 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature