Lurasidone inhibits NMDA receptor antagonist-induced functional abnormality of thalamocortical glutamatergic transmission via 5-HT₇ receptor blockade.

ABSTRACT:

Background and purpose

Lurasidone is an atypical mood-stabilizing antipsychotic with a unique receptor-binding profile, including 5-HT₇ receptor antagonism; however, the detailed effects of 5-HT₇ receptor antagonism on various transmitter systems relevant to schizophrenia, particularly the thalamo-insular glutamatergic system and the underlying mechanisms, are yet to be clarified.

Experimental approach

We examined the mechanisms underlying the clinical effects of lurasidone by measuring the release of l-glutamate, GABA, dopamine, and noradrenaline in the reticular thalamic nucleus (RTN), mediodorsal thalamic nucleus (MDTN) and insula of freely moving rats in response to systemic injection or local infusion of lurasidone or MK-801 using multiprobe microd

SUBMITTER: Okada M 

PROVIDER: S-EPMC6811777 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature