Connectome-Based Patterns of First-Episode Medication-Naive Patients With Schizophrenia.

ABSTRACT: Emerging evidence indicates that a disruption in brain network organization may play an important role in the pathophysiology of schizophrenia. The neuroimaging fingerprint reflecting the pathophysiology of first-episode schizophrenia remains to be identified. Here, we aimed at characterizing the connectome organization of first-episode medication-naïve patients with schizophrenia. A cross-sectional structural and functional neuroimaging study using two independent samples (principal dataset including 42 medication-naïve, previously untreated patients and 48 healthy controls; replication dataset including 39 first-episode patients [10 untreated patients] and 66 healthy controls) was performed. Brain network architecture was assessed by means of white matter fiber integrity measures derived

SUBMITTER: Cui LB 

PROVIDER: S-EPMC6811827 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature