A Caenorhabditis elegans ortholog of human selenium-binding protein 1 is a pro-aging factor protecting against selenite toxicity.

ABSTRACT: Human selenium-binding protein 1 (SELENBP1) was originally identified as a protein binding selenium, most likely as selenite. SELENBP1 is associated with cellular redox and thiol homeostasis in several respects, including its established role as a methanethiol oxidase that is involved in degradation of methanethiol, a methionine catabolite, generating hydrogen sulfide (H₂S) and hydrogen peroxide (H₂O₂). As both H₂S and reactive oxygen species (such as H₂O₂) are major regulators of Caenorhabditis elegans lifespan and stress resistance, we hypothesized that a SELENBP1 ortholog in C. elegans would likely be involved in regulating these aspects. Here we characterize Y37A1B.5, a putative selenium-binding protein 1 ortholog in C.

SUBMITTER: Kohnlein K 

PROVIDER: S-EPMC6812014 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature