Sex-specific metabolic functions of adipose Lipocalin-2.

ABSTRACT:

Objective

Lipocalin-2 (LCN2) is a secreted protein involved in innate immunity and has also been associated with several cardiometabolic traits in both mouse and human studies. However, the causal relationship of LCN2 to these traits is unclear, and most studies have examined only males.

Methods

Using adeno-associated viral vectors we expressed LCN2 in either adipose or liver in a tissue specific manner on the background of a whole-body Lcn2 knockout or wildtype mice. Metabolic phenotypes including body weight, body composition, plasma and liver lipids, glucose homeostasis, insulin resistance, mitochondrial phenotyping, and metabolic cage studies were monitored.

Results

We studied the genetics of LCN2 expression and associated clinical traits in both males and females

SUBMITTER: Chella Krishnan K 

PROVIDER: S-EPMC6812340 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature