Impaired adult hippocampal neurogenesis in a mouse model of familial hypercholesterolemia: A role for the LDL receptor and cholesterol metabolism in adult neural precursor cells.

ABSTRACT:

Objective

In familial hypercholesterolemia (FH), mutations in the low-density lipoprotein (LDL) receptor (LDLr) gene result in increased plasma LDL cholesterol. Clinical and preclinical studies have revealed an association between FH and hippocampus-related memory and mood impairment. We here asked whether hippocampal pathology in FH might be a consequence of compromised adult hippocampal neurogenesis.

Methods

We evaluated hippocampus-dependent behavior and neurogenesis in adult C57BL/6JRj and LDLr^-/- mice. We investigated the effects of elevated cholesterol and the function of LDLr in neural precursor cells (NPC) isolated from adult C57BL/6JRj mice in vitro.

Results

Behavioral tests revealed that adult LDLr^-/- mice showed reduced performance in

SUBMITTER: Engel DF 

PROVIDER: S-EPMC6812372 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature