Corona Composition Can Affect the Mechanisms Cells Use to Internalize Nanoparticles.

ABSTRACT: Nanosized objects, such as nanoparticles and other drug carriers used in nanomedicine, once in contact with biological environments are modified by adsorption of biomolecules on their surface. The presence of this corona strongly affects the following interactions at cell and organism levels. It has been shown that corona proteins can be recognized by cell receptors. However, it is not known whether the composition of this acquired layer can also affect the mechanisms nanoparticles use to enter cells. This is of particular importance when considering that the same nanoparticles can form different coronas for instance in vitro when exposed to cells in different serum amounts or in vivo depending on the exposure or administration route. Thus, in this work, different coronas wer

SUBMITTER: Francia V 

PROVIDER: S-EPMC6812477 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature